Cire Licorice: Buɗe Ci gaban Kimiyya Na Baka "Super{0}}Photon" Licochalcone A Don Farin Ciki

"Fatar fata tana ɓoye aibi ɗari, fata mai duhu tana lalata komai."

A matsayin daya daga cikin manyan kasuwannin duniya na kayayyakin kwalliya na baka, ana sa ran girman kasuwar kasar Sin zai kai25.57 biliyan RMB a 2025, ci gaba wajen zama babbar kasuwa a duniya tare da a3.8% adadin girma na shekara-shekara.
A cikin sashin kyawun baka na kasar Sin, daKashin fari yana fuskantar girma mai fashewa. Misali, akan JD.com a cikinfarkon kwata na 2025(Hoto na 1),sama da sabbin SKUs 3,500an ƙaddamar da shi a cikin sashin farar fata{0}}lissafin kusan kashi 90% na duk sabbin kayan kwalliyar bakaa daidai wannan lokacin, ya zarce sauran nau'i-nau'i irin su anti- tsufa, hydration, da asarar gashi{3}} [1].

Tsananin Haɗuwa da Sinadaran Farin Ciki -Ana Bukatar Sabbin Ayyuka Cikin Gaggawa

Abubuwan da ake amfani da su na baki a halin yanzu a kasuwa sun haɗa daglutathione, ergothionine, kumafarin tumatir tsantsa. Biyu na farko sun fi mayar da hankali kan da'awarsuantioxidation da free - radical scavenging, yayin da na karshen ya haskaka taphotoprotectiveamfanin (Table 1).

Duk da haka, alamu na kowane girma suna fuskantar gajiya ra'ayi. Kayayyakin farar fata suna ƙara kama da juna dangane da zaɓin kayan masarufi, yana haifar da masu amfani da su rasa sha'awar waɗannan ƙima mai maimaitawa. Kasuwar tana bukatar gaggawasabbin ayyukan farar bakidon shigar da sabon kuzari a cikin nau'in kyawun baka mai tsayayye.

Amsar wannan buƙatar na iya kasancewa a cikinbangaren kayan shafawa.

Tare da haɓakar yanayin "kayan shafawa-abincin abinci" yanayin, sashin kula da fata ya haifar da shahararrun ra'ayoyin kayan masarufi don nau'in kyawun baka.ErgothionineYa samo asali ne daga alamar Helena RubinsteinBaki Bandagecream (Hoto 2), wanda Daga baya Lift ya canza zuwa samfurin baka na "Ice Crystal Skin" (Hoto 3). Ma'anarastaxanthinya fito daga PROYABiyu Antilayi (Hoto na 4), sai na Ni YauHasken Haske(Hoto na 5).

Na gaba m sinadaran star,glabridin, mai tushe daga Guyu'sAurora Licoricejerin (Hoto na 6). Wannan layin fari, wanda ke kan glabridin, ya taimaka wa Guyu cimma nasara5 biliyan RMB a cikin GMV. Kamar yadda babban kamfanin kula da fata na kasar Sin da aka gina a kusa da glabridin, Guyu ya nuna girma mai fashewa wanda ya zarce samfuran gida kamar PROYA da Kans.

Duk da haka, a cikin gidakyawun bakaBangaran, glabridin ya kasance ba a taɓa amfani da shi ba{0}}yana ƙirƙirar sabuwar damammaki ga samfuran kyau na baka.

Figures 2 & 3: Helena Rubinstein Black Bandage da Daga baya Lift Ice Crystal Skin (wanda ya ƙunshi ergothioneine)

Figures 4 & 5: PROYA Double Anti da Ni A Yau Glow Shot (wanda ya ƙunshi astaxanthin)

Hoto 6: Guyu Aurora Licorice Series (wanda aka tsara tare da glabridin)

Hanyoyi na Licorice a cikin Farin fata

Licorice yana da dogon tarihi na amfani da kayan abinci da na magani a China kuma an rarraba shi azaman abiyu{0}amfani da abinci-maganisashi. A cikin tsarin kyan gargajiya na gargajiya na kasar Sin"San Bai Gan Cao Tang", Licorice yana haɗuwa tare da Atractylodes, White Peony, da Poria don magance matsalolin fata irin su hyperpigmentation, melasma, roughness, da bushewa. Hakanan ana haɗa Licorice a cikin sanannun sanannun magungunan farar fata na gargajiya kamar"Yu Rong San"kuma"Yu Nü Tao Hua Fen."

Bincike na zamani ya nuna cewa licorice ya ƙunshi abubuwan da ke haifar da bioactive kamar suglycyrrhizin, glycyrrhetinic acid, kumaglabridin, wanda ke da tasiri mai tasiri ga melanocytes da aka fallasa ga lalacewar hoto, damuwa na oxidative, da ƙumburi mai kumburi{0}} yana rage yuwuwar samar da melanin mai yawa. Bugu da ƙari, licorice na iya rage matakan melanin tahana tyrosinase, mahimmin enzyme da ke cikin melanogenesis.

"Oral Super Photonic" - Glabridin

Akwai nau'ikan licorice da yawa, kuma uku an halatta su yi amfani da su a China:Glycyrrhiza uralensis, Glycyrrhiza inflata, kumaGlycyrrhiza glabra. Glabridin, wani sinadari na musamman na bioactive da aka samu keɓaɓɓen a cikiGlycyrrhiza glabra, yana buƙatar shekaru da yawa na girma don tarawa kuma a zahiri yana nan a ƙananan matakai.
Daga1,000 kg na G. glabra shuke-shuke, kawai0.1 kg na glabridinza a iya fitar da - 1:10,000 rabon hakowa wanda ke nuna ƙarancinsa.

A lokaci guda, glabridin yana nunawana ƙwarai m m whitening inganci, samun sunansa a matsayin"Oral Super photonic" sashi. Ya riga ya sami karɓuwa sosai a fannin kula da fata kuma manyan samfuran kyaututtuka sun karɓe shi sosai.

Mai hana Tyrosinase mai ƙarfi ***

Bayan maganin antioxidant da anti-mai kumburi, mafi kyawun aikin glabridin yana cikin ta.tasirin hanawa mai ƙarfi akan tyrosinase. Daga cikin duk sanannun tsire-tsire da aka samo asali{1}, yana da 'yan kishiyoyi kaɗan, kuma ƙarfin hana shi shinemuhimmanci mafi girmafiye da masu hana tyrosinase da aka saba amfani da su kamar suruwa acidkumaarbutin.

Dangane da binciken da aka buga [2], glabridin yana aiki kamar aƘofar kwayoyin -kulle, toshe damar zuwa cibiyar catalytic na tyrosinase. Ta hanyar hana tyrosine shiga wurin aiki da kuma jurewa canji na gaba, glabridin yadda ya kamata.yana katse haɗin melanin a tushen sa.

Hoto na 8:
A: Idan babu glabridin, tyrosine (duhu blue) zai iya shiga cibiyar catalytic (blue mai haske) kuma a hankali ya canza zuwa melanin.
B: A gaban glabridin (mai haske kore), ƙofar zuwa cibiyar catalytic an toshe, yana hana tyrosine shiga.

Dangane da bayanan gwaji daga cibiyar ƙungiya ta uku - [4], ayyukan hana tyrosinase na Licochalcone A da LicoSnow cirewar licorice sun fi na samfuran makamantansu. Gwajin ya yi amfani da rabin{3}}mafi girman inhibitory taro (IC50) na tyrosinase a matsayin ma'aunin kimantawa. Wannan alamar tana wakiltar ƙaddamar da albarkatun da ake buƙata don hana 50% na ayyukan tyrosinase. Ƙananan darajar IC50 yana nuna cewa albarkatun kasa suna nuna tasiri mai mahimmanci a cikin ƙananan ƙaddamarwa, yana nuna ƙarfin tyrosinase hanawa.

Don tabbatar da adalci, an raba gwajin zuwa ƙungiyoyin kwatance biyu:

Rukuni na 1: High-purity raw materials (purity >98%), ciki har da Licochalcone A, glutathione, ergothioneine, da kojic acid (kyakkyawan iko don hana tyrosinase), jimillar abubuwa huɗu.

Rukuni na 2:Cire tsire-tsire, ciki har da LicoSnow tsantsa ruwan licorice (mai ɗauke da 4% Licochalcone A), ƙoshin ƙoshin guna (mai ɗauke da SOD), da farar ƙwayar tumatir (mai ɗauke da dihydro-/tetrahydro-lycopene), jimillar kayan uku.

Ana nuna ƙimar IC50 na kowane albarkatun ƙasa a cikin Tebur 2.

Dangane da dabi'un IC50, an kwatanta aikin inhibitory na tyrosinase na ƙungiyoyin biyu a cikin Figures 9 da 10. A cikin rukuni na 1, aikin hana tyrosinase na Licochalcone A shine sau 1.4 na glutathione, sau 3 na kojic acid, da 141 sau na . A cikin rukuni na 2, aikin hana tyrosinase na LicoSnow licorice tsantsa shine sau 11 na guna mai daɗaɗɗen foda da kuma sau 6,930 na farin farar tumatir.

Tabbatarwa na asibiti na Farin Baki tare da Licorice

Kodayake tasirin fata na Licochalcone A ya daɗe da sanin al'ummar kimiyya kuma yana ƙara ƙima a cikin masana'antar kula da fata, ba a ba da rahoton binciken ɗan adam da aka buga game da tasirin fatar baki ba. LicoSnow Cire licorice (wanda ya ƙunshi 4% Licochalcone A) daidai ya cika wannan gibin.

Sinadaran Huasheng, tare da haɗin gwiwar wata sanannen - -wata cibiyar gwajin jam'iyya, sun gudanar da gwajin ɗan adam na wata 1 da ya ƙunshi mahalarta 34 (mata masu shekaru 25-50) [5]. Mahalarta sun sha baki da baki 100 MG na LicoSnow tsantsa ruwan licorice kowace rana (wanda ya ƙunshi 4 MG Licochalcone A). An kimanta tasirin fari ta hanyar ma'auni na tushen kayan aiki da tambayoyin tambayoyi. Sakamakon gwaji sune kamar haka:

Rage launin fatar fuska (16%↓):
Bayan kwanaki 28 na amfani, yankin launin fatar fuska ya ragu daga 19.87% zuwa 16.65%, raguwar 16.21% (p=0.004), yana nuna bambanci mai mahimmanci kafin da bayan kari. Ana nuna kwatancen launin fuskar mahalarta a cikin hoto na 11.

Hoto 11: Canje-canje a cikin launi na fuska; hagu: kafin amfani, dama: bayan cinyewa

Haɓaka annurin fata (21%↑):
Bayan kwanaki 28, annurin fatar fuska ya ƙaru daga 4.0% zuwa 4.84%, haɓakar 21.00% (p=0.014), yana nuna babban bambanci kafin da bayan kari. Ana nuna kwatancen annurin fatar mahalarta a cikin hoto na 12.

Hoto 12: Canje-canje a annurin fatar fuska; hagu: kafin amfani, dama: bayan cinyewa

Ragewa a post{0}}UV pigmentation (15%↓):
An yi amfani da hasken UV na wucin gadi a bayan mahalarta don ƙirƙirar wuraren tanning. Kwanaki biyu bayan hasarar iska, an auna rarraba launin launi don kimanta post{1}}UV pigmentation. An dauki ma'auni a farkon kari (D-2 irradiation, D0 ma'auni) da kuma a karshen (D28 irradiation, D30 ma'auni). Bayan kwanaki 28, ƙimar melanin a cikin wuraren tanned sun ragu daga 99 zuwa 84, raguwa na 15.15% (p <0.001), yana nuna bambanci mai mahimmanci kafin da bayan kari.

Rage jajayen fata (28%↓):
Bayan kwanaki 28, ƙimar ja (a * darajar, mafi girma dabi'u suna nuna fata fata) na baya ya ragu daga 10.70 zuwa 7.69, raguwa na 28.13% (p <0.001), yana nuna bambanci mai mahimmanci kafin da bayan kari.

Gabaɗaya inganta fata (≈90% na mahalarta sun yarda):
Bayan kwanaki 28, kusan kashi 90% na mahalarta sun ba da rahoton ci gaban fata gaba ɗaya, kamar ƙarar sautin fata ko da haske, haɓakar annuri, da rage saurin tanning ko ja.

Kyakkyawan bayanin martaba:
Ba a lura da mummunan halayen ba yayin lokacin gwaji.

Magana:
[1] Cibiyar Bincike ta Boguang.Rahoton Binciken Kasuwar Kyau ta Baka ta China 2025.
[2] Chen J, Yu X, Huang Y.Hanyoyin hana glabridin akan tyrosinase.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2016 Nov 5;168:111-117.
[3] Rahoton gwajin da Shenzhen 863 Cibiyar Gwaji ta bayar.
[4] Rahoton gwajin ɗan adam wanda Huace Testing ya bayar.